Dr Laure Peter-Derex

Ludivine Deschamps de Boishebert (occupational medicine resident) , Dr Hélène Bastuji (Center for Sleep Mecicine and Respiratory Disease, HCL; Neuropain, CRNL), Dr François Ricordeau (Center for Sleep Mecicine and Respiratory Disease, HCL), Dr Thierry Petitjean (Center for Sleep Mecicine and Respiratory Disease, HCL), Pierre Pradat (Clinical Research Center, biostatistics, HCL), Dr Mélanie Strauss (Center for Research in Cognition and Neurosciences, Bruxelles)


Excessive daytime sleepiness (EDS) is a major public health issue affecting more than 5% of the general population. Its main causes are sleep deprivation, sedative treatments and sleep disorders, among which sleep apnea syndrome. EDS is responsible for cognitive impairments which can lead to poor academic and professional performances and to increased accidental risk especially at wheel. EDS’ assessment relies on subjective scales and objective laboratory vigilance tests. The Maintenance of Wakefulness Test (MWT) measures the ability not to fall asleep in passive conditions. By definition, sleep latency during MWT is defined by the appearance of at least 15sec of sleep on a 30 sec epochs while a few seconds of inattention or drowsiness are likely to be fatal in high speed driving conditions. One can therefore question the relevance of taking into account “micro-sleep” (ie short periods of sleep intrusion during wakefulness, mirrored phenomena of arousal during sleep) in MWT interpretation. “Microsleep 1” is a retrospective study designed to assess diagnosis value of microsleep latency as compared to sleep latency for investigation of sleepiness evaluated by questionnaires, and for prediction of accidental risk evaluated by car accident history. The study takes place in the Center for Sleep Medicine and respiratory Diseases in Lyon, HCL.


  • Peter-Derex L., Magnin M. Bastuji, H. Heterogeneity of arousals in human sleep: a stereo-electroencephalographic study. Neuroimage,2015; 123: 229-44.
  • Peter-Derex L, Perrin F, Petitjean T, Garcia-Larrea L, Bastuji H. Discriminating neurological from psychiatric hypersomnia using forced awakening test. Clinical Neurophysiology,2013; 43: 171-9.