Chercheure

Sommeil et santé métabolique

Mes travaux s’intéressent à l’impact de différentes caractéristiques du sommeil (durée, qualité, timing, régularité) dans la pathophysiologie des maladies métaboliques chez des enfants, des adolescents et des adultes de poids normal, obèses et/ou diabétiques. Mon objectif principal est de déterminer les effets préventifs et thérapeutiques d’une optimisation du sommeil sur la santé métabolique.

Publications

Original Articles

  • Thiesse L., Rudzik F., Krämer J.F., Spiegel K., Leproult R., Wessel N., Pieren R., Héritier H., Eze I.C., Foraster M., Garbazza C., Vienneau D, Brink M., Wunderli J.-M., Probst-Hensch N., Röösli M., Cajochen C. Transportation noise impairs cardiovascular function without altering sleep: the importance of autonomic arousals. Environment International. 2020 Mar;182:109086.
  • Thiesse L., Rudzik F., Spiegel K., LeproulT R., Pieren R., Wunderli J.-M., Foraster M., Héritier H., Eze I.C., Vienneau D, Meyer M., Brink M., Probst-Hensch N., Röösli M., Cajochen C. Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: effect of different noise scenarios. 2018, Dec;121(Pt 1):1011-1023.
  • Guyon A., Morselli LL, Balbo M, Tasali E., Leproult R., L’Hermite-Balériaux M., Van Cauter E, Spiegel K. Effects of insufficient sleep on pituitary-adrenocortical response to CRH stimulation in healthy men. Sleep. 2017 Jun 1; 40 (6).  
  • Guyon A., Balbo M, Morselli LL, Tasali E., Leproult R., L’Hermite-Balériaux M., Van Cauter E, Spiegel K. Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men. J. Clin. Endocrinol. Metab. 2014 Aug ;99 (8): 2861-8.
  • Inocente C.O., Lavault S., Lecendreux M., Dauvilliers Y., Reimãon R., Gustin M.-P., Lin J.-S., Spiegel K., Arnulf I., Franco P. Impact of obesity in children with narcolepsy. CNS Neuroscience & Therapeutics. 2013 Jul;19(7):521-8.
  • Morselli L.L., Nedeltcheva A., Leproult r., Spiegel K., Martino E., Legros J.-J., Weiss R.E., Mockel  J., Van Cauter e, Copinschi G. Impact of growth hormone replacement therapy on sleep in adult patients with growth hormone deficiency of pituitary origin. European Journal of Endocrinology. 2013 Apr 15;168(5):763-70.
  • Thorsley D., Leproult R., Spiegel K., ReifmanJ. A Phenomenological Model for Circadian and Sleep Allostatic Modulation of Plasma Cortisol Concentration. Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1190-201.
  • Spiegel K., Tasali E., Leproult r., Scherberg N., Van Cauter e. 24-h profiles of acylated and total ghrelin; relationship with glucose levels and impact of time of day and sleep.  J. Clin. Endocrinol. Metab. 96 (2011), 486-93.
  • Copinschi G., Nedeltcheva a., Leproult r., Morselli l.l., Spiegel K., Martino e., Legros j.j., Weiss r., Mockel j. Van Cauter e. Sleep disturbances and quality of life in adults with growth hormone deficiency. J. Clin. Endocrinol. Metab. 95 (2010), 2195-2202.
  • PARMENTIER R., ANACLET C., GUHENNEC C., BROUSSEAU E., BRICOUT D., GIBOULOT T., BOZYCZKO-COYNE D., SPIEGEL K., OHTSU H., WILLIAMS M., LIN J.S. The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. Biochemical Pharmacology., 73 (2007), 1157-71.
  • PENEV P, SPIEGEL K, MARCINKOWSKI T, VAN CAUTER E. Impact of carbohydrate-rich meals on plasma epinephrine levels: dysregulation with aging. J. Clin. Endocrinol. Metab, 90 (2005), 6198-206.
  • SPIEGEL K., TASALI E., PENEV P., VAN CAUTER E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Annals of Internal Medicine, 141 (2004), 846-50.
  • SPIEGEL K., LEPROULT R., L’HERMITE-BALERIAUX M., COPINSCHI G., PENEV P., VAN CAUTER E. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J. Clin. Endocrinol. Metab., 89 (2004), 5762-71.
  • SPIEGEL K., SHERIDAN J.F., VAN CAUTER E. Effect of sleep deprivation on response to immunization. JAMA, 288 (2002), 1471-1472.
  • SPIEGEL K., LEPROULT R., COLECCHIA E., L’HERMITE-BALERIAUX M., NIE Z., COPINSCHI G., VAN CAUTER E. Adaptation of the 24-hour growth hormone profile to a state of sleep debt. Am. J. Physiol.Regulatory Integrative Comp. Physiol., 279 (2000), R874-R883.
  • SPIEGEL K., LEPROULT R., VAN CAUTER E. Impact of a sleep debt on metabolic and endocrine function. Lancet, 354 (1999),1435-1439.
  • LINKOWSKI P., SPIEGEL K., KERKHOFS M., L’HERMITE-BALERIAUX M., VAN ONDERBERGEN A., LEPROULT R., MENDLEWICZ J., VAN CAUTER E. Genetic and environmental influences on prolactin secretion during wake and during sleep. Am. J. Physiol., 274 (1998), E909-E919.
  • WEIBEL L., SPIEGEL K., GRONFIER C., FOLLENIUS M., BRANDENBERGER G. Twenty-four hour melatonin and core body temperature rhythms: their adaptation in night workers. Am. J. Physiol., 272(1997), R948-R954.
  • WEIBEL L., FOLLENIUS M., SPIEGEL K., GRONFIER C., BRANDENBERGER G. Growth hormone secretion in night workers. Chronobiol. Internat., 14 (1997), 49-60.
  • WEIBEL L., SPIEGEL K., FOLLENIUS M., EHRHART J., BRANDENBERGER G. Internal dissociation of the circadian markers of the cortisol rhythm in regular night workers. Am. J. Physiol., 270 (1996), E608-E613.
  • SPIEGEL K., WEIBEL L., BRANDENBERGER G., FOLLENIUS M. Twenty-four hour prolactin profile in night workers. Chronobiol. Internat., 13 (1996), 283-293. IC ISI = 17.
  • CHAPOTOT F., GRONFIER C., SPIEGEL K., LUTHRINGER R., BRANDENBERGER G. Relationships between iPTH 24-hour profiles, sleep-wake cycle and sleep electroencephalic activity in man. J. Clin. Endocrinol. Metab., 81 (1996), 3759-3765.
  • BRANDENBERGER G., BUGUET A., SPIEGEL K., STANGHELLINI A., MUANGA G., BOGUI P., MONTMAYEUR A., DUMAS M. Disruption of endocrine rhythms in sleeping sickness with preserved relationship between hormonal pulsatility and the REM-NREM sleep cycles. J. Biol. Rhythms, 11 (1996), 258-267.
  • WEIBEL L., FOLLENIUS M., SPIEGEL K., EHRHART J., BRANDENBERGER G. Comparative effect of night and daytime sleep on the 24-hour cortisol secretory profile. Sleep, 18 (1995), 549-556.
  • WEIBEL L., BRANDENBERGER G., GOICHOT B., SPIEGEL K., EHRHART J., FOLLENIUS M. The circadian thyrotropin rhythm is delayed in regular night workers. Neurosci. Lett., 187 (1995), 83-86.
  • SPIEGEL K., LUTHRINGER R., FOLLENIUS M., SCHALTENBRAND N., MACHER J.P., MUZET A., BRANDENBERGER G. Temporal relationship between prolactin secretion and slow-wave electroencephalic activity during sleep. Sleep, 18 (1995), 543-548.
  • SPIEGEL K., FOLLENIUS M., KRIEGER J., SFORZA E., BRANDENBERGER G. Prolactin secretion during sleep in obstructive sleep apnoea patients. J. Sleep Res., 4 (1995), 56-62.
  • SAINI J., BOISVERT P., SPIEGEL K., CANDAS V., BRANDENBERGER G. Influence of alcohol on the hydromineral endocrine responses to exercise in a warm environment. Eur. J. Appl. Physiol., 72 (1995), 32-36.
  • LUTHRINGER R., BRANDENBERGER G., SCHALTENBRAND N., MULLER G., SPIEGEL K., MACHER J.P., MUZET A., FOLLENIUS M. Slow wave electroencephalic activity parallels renin oscillations during sleep in humans. Electroencephal. Clin. Neurophysiol., 95 (1995), 318-322.
  • BRANDENBERGER G., SCHNEDECKER B., SPIEGEL K., METTAUER B., GENY B., SACREZ J., LAMPERT E., LONSDORFER J. Parathyroid function in cardiac transplant patients : evaluation during physical exercise. Eur. J. Appl. Physiol., 70 (1995), 401-406.
  • SPIEGEL K., FOLLENIUS M., SIMON C., SAINI J., EHRHART J., BRANDENBERGER G. Prolactin secretion and sleep. Sleep, 17 (1994), 20-27.
  • FOLLENIUS M., SPIEGEL K., GRONFIER C., SAINI J., BRANDENBERGER G. Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action. J. Endocrinol. Invest., 17 (1994), 417-423.
  • BRANDENBERGER G., FOLLENIUS M., GOICHOT B., SAINI J., SPIEGEL K., EHRHART J., SIMON C. Twenty-four-hour profiles of plasma renin activity in relation to the sleep-wake cycle. J. Hypert., 12 (1994), 277-283.
  • BRANDENBERGER G., BUGUET A., SPIEGEL K., STANGHELLINI A., MUANGA G., BOGUI P., MONTMAYEUR A., DUMAS M. Maintien des relations entre la sécrétion pulsatile des hormones et la structure interne du sommeil dans la trypanosomiase africaine. Bull. Soc. Pathol. Exot., 87 (1994), 383-389.

Book Chapters

  • Spiegel K, Copinschi G. Fonction endocrino-métabolique et sommeil. Chapitre 22. In: Dauvilliers Y (ed): Les troubles du sommeil. 3ème édition. Elsevier Masson. 2019.
  • Spiegel K. Conséquences métaboliques de l’insomnie. In: Royant-Parola S., Brion A. & Poirot I. (eds): Prise en charge de l’insomnie. Elsevier Masson. 2017, pp 256.
  • Copinschi G., Leproult R., Spiegel K. The important role of sleep in metabolism. In: Aart J. van der Lely & Patric Delhanty (eds): How gut and brain control metabolism. Basel, Switzerland, S. Karger AG. 2014, pp. 59-72. Front Horm Res. 2014;42:59-72. doi: 10.1159/000358858. Epub 2014 Apr 7.
  • Leproult R., Spiegel K., Van Cauter E. Chapter 3.10: Endocrine Physiology. In: Meir H. Kryger, MD, FRCPC (ed): Atlas of clinical sleep medicine, Elsevier, Inc., 2009.
  • Leproult R., Spiegel K., Van Cauter E. Chapter 6.15: Sleep and endocrinology. In: Amlaner CJ and Fuller PM (ed). Basics of Sleep Guide, Second Edition. Westchester, Illinois: Sleep Research Society. 2009, pp 157-167.
  • Spiegel K., Leproult R., Van Cauter E. Metabolic and Endocrine Changes associated with sleep deprivation. In: Kushida Clete A (ed): SLEEP DEPRIVATION Volume 1: Basic Science, Physiology, and Behavior. New York, Marcel Dekker. 2005, pp. 293-318.
  • Buxton O.M., Spiegel K., Van Cauter E. Chapter 8: Modulation of endocrine function and metabolism by sleep and sleep loss. In: Lee-Chiong T.L., Sateia M.J., Carskadon M.A. (eds): Sleep Medicine, Handley & Belfus, Inc., Philadelphia, 2002, pp. 59-69.
  • Van Cauter E., Spiegel K. Circadian and sleep control of hormonal secretions. In: Turek Fred W. and Zee Phyllis C. (eds): Monograph on « Neurobiology of Sleep and Circadian Rhythms ». New York, Marcel Dekker, 1999, pp 397-425.
  • Brandenberger G., Gronfier C., Weibel L., Spiegel K., L R. Modulatory role of sleep on hormonal pulsatility. In: Hayaishi O., Inoue S. (eds): Sleep and Sleep Disorders: from Molecule to Behavior. Tokyo, Academic Press, 1997, pp 195-198.
  • Van Cauter E., Spiegel K. Hormones and metabolism during sleep. In : Schwartz W.J. (ed): Sleep Science: Integrating Basic Research and Clinical Practice. Monographs in Clinical Neuroscience. Basel, Karger, 1997, vol. 15, pp 144-174.

Reviews in international journals

  • Morselli L., Guyon A., Spiegel K. Sleep and metabolic function. Pflügers Archiv – European Journal of Physiology.2012; 463 (1) : 139-160.
  • Morselli L., Leproult R., Balbo M., Spiegel K. Role of sleep duration in the regulation of glucose metabolism and appetite. Best Pract Res Clin Endocrinol Metab. 2010 Oct;24(5):687-702.
  • Van Cauter E. & Spiegel K.  Sleep and diabesity. Obesity and Metabolism – Milan, 5 (Suppl. To No 2) (2009): 63-68.
  • Spiegel K., Tasali E, Leproult R, Van Cauter E E. Effects of poor and short sleep on glucose metabolism and obesity risk. Nature Reviews Endocrinology, 5 (2009): 253-261.
  • Tasali E, Leproult R, Spiegel K. Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes. Progress in Cardiovascular Diseases, 51 (2009): 381-391.
  • Van Cauter E E., Spiegel K Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Medicine, 9 Suppl. 1 (2008) S23-S28.
  • Buyse B., Hedner J. and the participants of working group 2 (Arnulf I, Becker H, Grote L., Hamans E., Harsch I., Hedner J., Javaheri S., Launois-Rollinat S., Lavie L., Lavie P., Lüthje L., Lévy P., Penzel Th., Poirrier R., Saaresranta T., Smith I., Spiegel K., Turkington P., Verstraeten E.). Chapter 6: Sleep apnoea, hypertension and vascular disease: where are we now ? Proceedings from the International Symposium on Respiratory Somnology (Leuven March 18, 2006). Eur. Respir. Rev., (Dec 2007); 16: 169 – 182.
  • Buyse B. and the participants of working group 2 (Arnulf I, Becker H, Grote L., Hamans E., Harsch I., Hedner J., Javaheri S., Launois-Rollinat S., Lavie L., Lavie P., Lüthje L., Lévy P., Penzel Th., Poirrier R., Saaresranta T., Smith I., Spiegel K., Turkington P., Verstraeten E.). Treatment effects of sleep apnoea; where are we now? Proceedings from the International Symposium on Respiratory Somnology (Leuven March 18, 2006). Eur. Respir. Rev., (Dec 2007); 16: 146 – 168.
  • Van Cauter E E., Holmback U., Knutson K.L., Leproult R., Miller A., Nedeltcheva A., Pannain S., Penev P., Tasali E., Spiegel K. Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function. Horm Res., 67 Suppl 1 (2007): 2-9.
  • Knutson K.L., Spiegel K., Penev P., Van Cauter E. The Metabolic Consequences of Sleep Deprivation. Sleep Med. Rev.”, 11 (2007), 163-178.
  • Spiegel K., Knutson K., Leproult R., Tasali E., Van Cauter E E. Sleep Loss: A Novel Risk Factor for Insulin Resistance and Type 2 Diabetes. J. of Appl. Physiol., 99 (2005), 2008-2019.
  • Van Cauter E., Latta F., Nedeltcheva A., Spiegel K., Leproult R., Vandenbril C., Weiss R., Mockel J., Legros J.-J., Copinschi G. Reciprocal interactions between the axis and sleep. Growth hormone & IGF Research, 14 (2004), S10-S17.
  • Van Reeth O., Weibel L., Spiegel K., Leproult R., Dugovic C., Maccari S. Interactions between stress and sleep: from basic research to clinical situations Sleep Med. Rev., 4 (2000), 201-219.
  • Van Cauter E E., Spiegel K. Sleep as a mediator of the relationship between socioeconomic status and health. Ann N Y Acad Sci., 896 (1999), 254-261.
  • Copinschi G., Spiegel K., Leproult R., Van Cauter E. Pathophysiology of human circadian rhythms. In: » Mechanisms and biological significance of pulsatile hormone secretion ». Novartis Foundation Symposium 227, John Wiley & Sons, Itd, Chichester, 2000, pp 143-162.

Invited talks and symposia at national and international meetings

  • Spiegel K. Invited Speaker. Evolution des rythmes de sommeil de l’enfant : une crise de santé publique ? E-Congrès National de l’association française de pédiatrie ambulatoire, Bordeaux, France, November 13 – 14, 2020.
  • Spiegel K. Invited Speaker. Effets métaboliques et cardiovasculaires de la privation de sommeil. Session «Sleep and metabolic health: time for behavioral sleep interventions? » IPSA 2018 : 5th Meeting of the International Pediatric Sleep Association, Paris, France, April 27 – 29, 2018.
  • Spiegel K. Chairman and Speaker. Effects of extended time in bed on food intake and glucose metabolism in young overweight habitual short sleepers: a randomized controlled study. Session « Sport – Anesthésie – Sommeil» CardioSleep 2018 : Syndrome d’apnée du sommeil « Le risque et le symptôme», 23-24 mars 2018, Cité Mondiale de Bordeaux, Bordeaux, France.
  • Spiegel K. Invited Speaker & Chairman. Axe hypophyso surrénalien : effets d’un déficit de sommeil sur son activité basale et sa réponse à une stimulation chez l’Homme. Symposium on “Sommeil et stress”. SFMRS 2017 – Congrès annuel de la Société Française de Recherche et Médecine du Sommeil, 23-25 Novembre 2017, Marseille, France.
  • Spiegel K. Invited Plenary Lecture. Conséquences d’un sommeil insuffisant sur le risqué d’obésité et de diabète. STMS 2018 – 2ème Congrès annuel de la Société Tunisienne de Médecine du Sommeil, 19-21October 2017, Tunis, Tunisie.
  • Spiegel K. Invited Plenary Lecture. Effets du sommeil et de la rythmicité circadienne sur la function endocrino-métabolique. STMS 2018 – 2ème Congrès annuel de la Société Tunisienne de Médecine du Sommeil, 19-21October 2017, Tunis, Tunisie.
  • Spiegel K. Invited Speaker. Clinical Impact of Sleep Deprivation and qua on Metabolic Risk. Symposium on “Sleep and circadian factors in metabolic risk: a translational perspective ». www.worldsleepcongress.com – A joint congress of the world association of sleep medicine and world sleep federation, October 2017, Prague, Czech Republic.
  • Spiegel K. Invited Speaker & Chairman. Extension du temps passé au lit chez des petits dormeurs obèses: effets sur le sommeil, la prise alimentaire et le métabolisme glucidique”. Symposium n “Payer sa dette de sommeil : quels effets sur la santé métabolique? » SFMRS 2016 – Congrès annuel de la Société Française de Recherche et Médecine du Sommeil, Novembre 2016, Strasbourg, France.
  • Spiegel K. Invited Speaker. “Sommeil et rythmicité circadienne: quels effets sur les sécrétions endocriniennes et la santé métabolique ?”. Symposium « Rythmes circadiens hormonaux : de leur conception à leurs implications en physiologie et pathologie humaines ». 41ème colloque de la SNE (société de neuroendocrinologie) & 5 ème colloque franco-québécois, Université de Corse Pasquale Paoli, 5-8 octobre 2016.
  • Spiegel K. Chairman. Session «Physiology of Sleep in Humans and Rodents». ESRS 2016 : Annual Meeting of the European Sleep Research Society, Bologna, Italy, September 13 – 16, 2016.
  • Spiegel K. Invited speaker. Sleep loss: implications for metabolic health and endocrine rhythmicity Joint ESRS/EBRS symposium. ESRS 2016 : Annual Meeting of the European Sleep Research Society, Bologna, Italy, September 13 – 16, 2016.
  • Spiegel K. Invited speaker. Sleep and glycaemic control in children with Type 1 diabetes. Symposium on “Optimizing nocturnal diabetes control”. ESPE 2016 : Annual Meeting of the European Society for Pediatric Endocrinology, Paris, France, September 10 – 12, 2016.
  • Spiegel K. Invited Speaker. “Répercussions métaboliques”. Session « Des répercussions à la prise en charge”. Symposium: Les troubles du sommeil et le SAOS chez l’adolescent. June 23-24, 2016.
  • Spiegel K. Invited Speaker. “ Sommeil et prise alimentaire”. Les 18ème Entretiens de Nutrition de l’Institut Pasteur de Lille. June 9-10, 2016.
  • Spiegel K. Invited Speaker. “Metabolic and endocrine consequences of sleep loss? » Journées Thématiques : Rythme circadien : la biologie à la mesure du temps. CIEP (Centre International d’Etudes Pédagogiques), Sèvres, France. March 18-20, 2016.
  • Spiegel K. Invited Speaker. “Sommeil court et poids: quels liens? » Journée Annuelle Benjamin Delessert  Delessert. Paris. February 5, 2016.
  • Spiegel K. Speaker. “ Métabolisme, nutrition et sommeil chez l’enfant”. “Symposium déjeunatoire” on “Epidémiologie du Sommeil – Sommeil et Nutrition”. SFMRS 2015 – Congrès annuel de la Société Française de Recherche et Médecine du Sommeil, Nantes, France, November 19-21, 2015.
  • SPIEGEL K. Speaker & Chairman. “Conséquences métaboliques du manque de sommeil”. Symposium on “Dormons-nous assez?” SFMRS 2015 – Congrès annuel de la Société Française de Recherche et Médecine du Sommeil, Nantes, France, November 19-21, 2015.
  • SPIEGEL K. Chairman. « Les troubles du sommeil » session. SFMRS 2014 – Congrès annuel de la Société Française de Recherche et Médecine du Sommeil, Lille, France, November 20-22, 2014.
  • SPIEGEL K. « Sleep and metabolic regulations ». Symposium on «Sleep, Metabolism and Obesity», Congress of the Italian Society of Obesity, Milan, Italy, July 2-5, 2014.
  • SPIEGEL K. Chairman. « Sleep and glucose metabolism » Symposium. World Congress on Sleep Medicine (WASM 2013), Valencia, Spain, September 28 – October 2, 2013.
  • SPIEGEL K. « Sommeil et métabolisme ». «5ème Symposium Francophone Novo Nordisk», Marseille, France, Mai 23-25, 2013.
  • SPIEGEL K. « Conséquences métaboliques d’un manque de sommeil ». P2T Congrès de Physiologie, de pharmacologie et thérapeutique, Angers, France, April 23-24, 2013.
  • SPIEGEL K. Invited speaker and CHAIRMAN. Symposium on “Sommeil, rythmicité circadienne et risque métabolique”. Conséquences métaboliques d’un sommeil de durée et de qualité altérées. SFRMS 2012, Bordeaux, France, November 22-24, 2012.
  • SPIEGEL K. Symposium on “Sleep and circadian rhythm”. Sleep loss and appetite regulation: implications for obesity. ESRS 2012 – 21st Congress of the European Sleep Research Society, Paris, France, Sept 4-8, 2012.
  • SPIEGEL K. Symposium on “Sleep and circadian rhythm”. Sleep and metabolism: implications for obesity. ECO2012 – 19th European Congress on Obesity. Lyon, France, May 9-12, 2012.
  • SpiegelK. KEYNOTE LECTURE. Sleep and the epidemic of obesity and diabetes. Annual meeting of the Italian Sleep Research Society (SIRS), Bologna, Italy, March 17-18, 2012.
  • SpiegelK.Privation de sommeil et diabète. Symposium Satellite VitalAire « Sommeil et Diabète. SFMRS 2011 – Congrès annuel de la Société Française de Recherche et Médecine du Sommeil, Strasbourg, France, November 24-26, 2011.
  • SPIEGEL K. Invited speaker. Symposium on “Pathologie du sommeil en endocrinologie”. Le manque de sommeil, un facteur de risque sous-estimé d’obésité et de diabète. 28ème congers de la société française d’endocrinologie. Clermont-Ferrand, France, October 10-13, 2011.
  • SPIEGEL K. Invited speaker. Symposium on “Medical Conditions and Sleep”. Sleep loss and accelerated metabolic aging. Aging and Sleep 2010. Lyon, France, June 25-26, 2010.
  • SPIEGEL K. Invited lecture. Session VII “Sleep and circadian rhythms”. Effects of poor and short sleep on glucose metabolism and obesity risk. XII Congress of the European Federation of Autonomic Societies. Giardini Naxox – Taormina, Sicily – Italy, May 12-15, 2010.
  • SPIEGEL K. Invited speaker. Symposium on “Sleep and obesity”. Sleep restriction and obesity. BASS Autumn Meeting. Castel de Pont-à-Lesse, Belgium, December 11, 2009.
  • SPIEGEL K. Invited speaker. Symposium on “New determinants of obesity”. The impact of sleep loss on obesity and diabetes risk. 17th European Congress on Obesity (ECO2009). May 6-9, 2009. Amsterdam, Netherlands.
  • SPIEGEL K. Invited speaker. Symposium on “SESSION N°26 : Symposium scientifique « Sommeil ». Privation de sommeil: conséquences métaboliques. P2T Congrès de Physiologie, de pharmacologie et thérapeutique. April 15-17, 2009. Marseille, France.
  • SPIEGEL K. Invited speaker. Symposium on “Quand le sommeil nous manque”. Répercussions métaboliques de la privation de sommeil. Journées de Neurologie de Langue Française. April 1-4, 2009. Lille, France.
  • SPIEGEL K. Invited speaker. Symposium on “Sleep Deprivation”. Metabolic impact of sleep duration and sleep quality. The 50th Anniversary of Paradoxical Sleep Discovery. January 7-10, 2009. Lyon, France.
  • SPIEGEL K. Invited speaker. Symposium on “Regulation of hypothalamic-pituitary crosstaltk”. “Alterations in metabolism induced by sleep loss”. ISE (International Society of Endocrinology) Meeting, Rio de Janeiro, Brazil, November 8 – 12, 2008.
  • SPIEGEL K. Invited speaker. Symposium on “S6 Neuroendocrinology, Sleep and Obesity”. Sleep, obesity and neuro-endocrine hormones. 13th meeting of the European Endocrine Association (ENEA), Antalya, Turkey, October 17 – 20, 2008.
  • SPIEGEL K. Invited speaker. Symposium on “Consequences of restricted sleep: adaptive or maladaptive?”. Regulation of sleep, hunger and metabolism: consequences of recurrent sleep restriction. 19th Congress of the European Sleep Research Society, Glasgow, Scotland, September 9 – 13th, 2008.
  • SPIEGEL K. Invited speaker. Symposium on “Sleep and Obesity?”. Metabolic consequences of sleep deprivation. Congress of the Spanish Sleep Research Society, Palma de Majorque, Spain, June 22 – 24th, 2008.
  • SPIEGEL K. “Reduced sleep duration and quality; impact on the risk for obesity and diabetes”. Invited lecture. Satellite on childhood obesity to the 16th European Congress of Obesity, Geneva, Switzerland, May 13, 2008.
  • SPIEGEL K., et al. Invited speaker. Symposium on “Sleep and its disorders: Impact on hormones and metabolism”. Sleep loss as a risk factor for obesity. 27th European Winter Conference on Brain Research (EWCBR), Villars sur Ollon, Switzerland, March 10-17, 2007.
  • SPIEGEL K. Invited speaker. Symposium on “Sleep, neuro-hormones and metabolism”. Impact of sleep restriction on human carbohydrate and appetite regulation. 12th Meeting of the European Neuroendocrine Association, Athens October 21-24, 2006.
  • SPIEGEL K. Invited speaker. Symposium on “Horloge circadienne et rythmes hormonaux: de la physiologie à la pathologie”. Impact du sommeil et de la rythmicité circadienne sur le métabolisme glucidique et la regulation neuroendocrinienne de l’appétit”. 23ème Congrès de la Société Française d’Endocrinologie, Montpellier September 27-30, 2006.
  • SPIEGEL K. Workshop moderator on “Sleep and metabolism / obesity”. 4th International Sleep Disorders Forum “the Art of Good Sleep” Rome, September 7-8, 2006.
  • SPIEGEL K. Invited speaker. Symposium on “Sleep, hormones, metabolism and nutrition”. Endocrine and metabolic consequences of sleep loss. Madrid, April 28, 2006.
  • SPIEGEL K. Invited speaker. Session on “The Connection Between Sleep and Obesity: The Evidence from Humans”. Carbohydrate Metabolism and Appetite Regulation. Workshop on Sleep and Obesity organized by the National Sleep Foundation and the International Life Sciences Institute – North America, March 27-28, 2006.
  • SPIEGEL K. Invited speaker. “Sleep Loss: A Novel Risk Factor for obesity”. Meeting of the Belgium Association for the Study of Obesity (BASO), Brussels, March 25, 2006.
  • SPIEGEL K. Invited speaker. “Leptin and ghrelin”. 7th International Symposium of K.U. Leuven: « Respiratory Somnology: A clinical update », March 16-18, 2006.
  • SPIEGEL K. Invited speaker. Symposium. « Durée et qualité du sommeil: répercussions métaboliques ». XXème Congrès de la Société Française de Recherche sur le Sommeil, Lyon, France November 24-26, 2005.
  • SPIEGEL K, Guilleminault C. Chairmanship. Young Investigator Symposium. World Association of Sleep Medicine, Berlin, Germany October 16-18, 2005.
  • SPIEGEL K, POLOTSKY VY. Chairmanship. Oral session 03 on “Physiology and Endocrinology”. World Association of Sleep Medicine, Berlin, Germany October 16-18, 2005.
  • SPIEGEL K. Invited speaker. Symposium on “Metabolic Complications of Sleep Disorders”. Metabolic Effects of Sleep Deprivation. World Association of Sleep Medicine, Berlin, Germany October 16-18, 2005.
  • SPIEGEL K. Invited speaker. Symposium on “Neuro-immuno-endocrinology of sleep disorders and emotional stress”. Metabolic effects of sleep loss. 6th International Congress of NeuroImmunoModulation, Athens September 25-28, 2005.
  • SPIEGEL K. Invited speaker. Symposium on “Medical Chronobiology”. The circadian and sleep/wake aspects of metabolic imbalance. 19th Annual APSS Meeting, Denvers, Colorado, USA, June 18-23 2005. Presentation selected to be posted on CMEonSleep.com, a website for healthcare professionals treating patients affected by sleep.
  • SPIEGEL K. Chairman and speaker. Symposium on “Sleep, metabolism and weight regulation”. Sleep Loss and Metabolism. 19th European Sleep Research Society (ESRS) Congress, Prague, Czech Republic, October 2004.
  • SPIEGEL K. Sleep loss as a risk factor for obesity, diabetes and the metabolic syndrome. 6th Annual International Symposium Kempenhaeghe “Epilepsie and Sleep Update @ Kempenhaeghe.nl”, Kempenhaeghe, Netherlands, Heeze, March 26, 2004.
  • SPIEGEL K. Invited speaker. Symposium on “Metabolic aspects of sleep and sleep-disordered breathing”. Effect of Sleep Deprivation on Obesity, Hormones and Glucose Control. World Congress on Sleep Apnea, Helsinki, Finland, June 29 – July 3, 2003.
  • SPIEGEL K. Invited speaker. Symposium on “Disturbed Sleep And The Metabolic Syndrome”. Metabolic and endocrine impact of sleep curtailment. 17th Annual APSS Meeting, Chicago, Illinois, USA, June 2003.
  • SPIEGEL K., Leproult R., Tasali E., Penev P., Van Cauter E. Invited speaker. Symposium on “Sleep Loss and the Metabolic Syndrome”. Sleep duration is a major determinant of leptin levels, hunger and appetite. XXXIII Annual Congress of the International Society of Psychoneuroendocrinology, Pisa, Italy, March 2003. Abstract number S13.
  • SPIEGEL K. Invited speaker. Plenary session on “Rythme et Sommeil”. Impact d’une dette de sommeil sur les rythmes physiologiques. Meeting of the “Societé Française de Recherche sur le Sommeil”, Strasbourg, France, November 2002.
  • SPIEGEL K., LEPROULT R., COPINSCHI G., VAN CAUTER E. Invited speaker. Session on “Health impact of sleep loss and sleep disturbances”. Leptin and hypothalamo-pituitary-adrenal axis regulation in a state of sleep debt. 15th Annual APSS Meeting, Chicago, Illinois, USA, June 2001.
  • VAN CAUTER E.,LEPROULT R., SPIEGEL K. Hormonal systems and sleep deprivation. 5th international meeting on sleep, Bordeaux, France, April 2001.
  • SPIEGEL K., LEPROULT R., VAN CAUTER E. Invited speaker. Session on “Sleep restriction: its behavioral and biological consequences”. Leptin and hypothalamo-pituitary-adrenal axis regulation in a state of sleep debt. 21st European Winter Conference on Brain Research (EWCBR), Les Arcs, France, March 2001.
  • SPIEGEL K. Invited speaker. Impact of sleep deprivation on endocrine functions. Second International Congress on Hormones, Brain and Neuropsychopharmacology, Rhodes, July 2000.
  • SPIEGEL K. Invited speaker. The role of sleep in physiological repair. Berzelius Symposium 50 of the Swedish Society of Medicine, Stockholm, Sweden, May 2000.
  • SPIEGEL K., LEPROULT R., STICKGOLD R., VAN CAUTER E. Invited speaker. Impact of a sleep debt on metabolic and endocrine function. Third International Congress of the World Federation of Sleep Research Societies, Dresden, Germany, October 1999.
  • VAN CAUTER E, SPIEGEL K. Effects of sleep deprivation on glucose tolerance. International Congress on Chronobiology, Washington, DC, USA, August-September 1999.
  • SPIEGEL K., SANTUCCI J., COLECCHIA E.F., KOSSLYN S.M., VAN CAUTER E. Invited speaker. Waking function in a state of sleep debt. 19th European Winter Conference on Brain Research (EWCBR), Plagne Lauze, France, March 1999.

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E-mail professionnel : karine.spiegel [at] univ-lyon1.fr

ResearcherID : https://publons.com/researcher/2112925/karine-spiegel/